Gene Therapy Vectors

AAV vs. Lentivirus vs. LNP: How the Three Leading Gene Therapy Vectors Compare on Payload, Immunogenicity, and Persistence

Selecting the optimal gene therapy vector among AAV, lentivirus, and LNPs requires a strategic trade-off between payload capacity, immunogenicity, and desired expression duration. Each vector platform occupies a distinct niche based on its unique characteristics and therapeutic application.